Administration of N-acetylcysteine (Nac) as Adjunctive Therapy for Covid-19 Patients by Improving Oxidative Stress and Inflammation through Assessment of Ldh, Crp, D-dimer, and Ferritin

INTRODUCTION Lactate dehydrogenase (LDH), C-Reactive Protein (CRP), D-dimer and feritin are acute phase proteins which levels may rise in the presence of an inflammatory process COVID-19. N-Acetylcysteine (NAC) is antioxidant has also been widely considered as adjunctive therapy We aim to analyze effect NAC administration improving oxidative stress inflammation COVID-19 through assessment LDH, CRP, D-dimer, levels. METHOD A quasi-experimental study with pre-post design. were measured admission day 8 5000 mg/72 hours NAC. RESULT There a significant decrease Ferritin between therapy. CRP reduced from 185.31 ± 181.30 97.60 161.86 (p<0.001), LDH 4.65 4.13 1.87 0.96 (p<0.001) (p<0.001). DISCUSSION day-1 (admission) day-8 accordance existing theories. This implies ability reduce patients. CONCLUSION was after patients positive correlation severity mortality towards protein